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NAD(P)+ transhydrogenase (Si-specific) : ウィキペディア英語版 | NAD(P)+ transhydrogenase (Si-specific)
In biochemistry, NAD(P)+ transhydrogenase (''Si''-specific) () is an enzyme that catalyzes the chemical reaction :NADPH + NAD+ NADP+ + NADH Thus, the two substrates of this enzyme are NADPH and NAD+, whereas its two products are NADP+ and NADH. This enzyme participates in nicotinate and nicotinamide metabolism. It employs one cofactor, FAD. == Physiological function ==
''Si''-specific transhydrogenase is a soluble protein found in some Gammaproteobacteria and gram-positive bacteria. Enterobacteriaceae are known to possess both a soluble and a membrane-bound transhydrogenase. In living cells this enzyme primarily operates in the direction consuming NADPH and producing NADH, as the physiological ratio of NADPH/NADP+ is much higher than the ratio of NADH/NAD+.〔 Its chief function ''in vivo'' is the reoxidization of excess NADPH.
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